Student scholars
Ufumes scholars banner
UFUMES SCHOLARS... The Nigerian Online Publishing Press
UfUMES SCHOLARS home Publishing in UFUMES SCHOLARS scholarly works published in ufumes scholars Affiliate programs in UFUMES SCHOLARS About UFUMES SCHOLARS Online Educational Resources
Aminoacyl-tRNA Synthetase (AaRS); a promising target for antibiotic drugs
Chimaobi J. Ononamadu* , Onyinye S. Udoh* (2009)
Dept of Applied biochemistry, Nnamdi Azikiwe University. Awka. Nigeria. ( Review Article)
Correspondence to: Ononamadu Chimaobi. chymaonos@yahoo.com, +2348037202476
Abstract
Aminoacyl-tRNA synthetase (AaRs) enzymes are essentially critical in the biosynthesis of proteins. They catalyze the synthesis of aminoacyl-tRNAs (aa-rRNA).There is a growing evidence that aminoacyl-tRNA synthetases could represent a broad target for antibiotics and antibacterial agents with the growing emergence of AaRs inhibitors like, Indolmycin (which targets TrpRs) Chuangxinmycin (which targets ThrRs ) Granaticin (which targets leuRs ) Furanomycin (which targets IleRs), Ochratoxin A (which targets ProRS, ). REP 8839 (which targets metRS) SB- 219383 (which targets TyrRs) and Mupirocin Presently, mupirocin is the only commercially available antibiotic that inhibits bacterial AaRs, and it has proven to be a potent competitive inhibitor of Iso-Leucyl tRNA synthetase in Staphylococcus aureus. Despite the high potency, high and low level resistances have been reported in mupirocin clinical use as a result of acquired foreign gene (mupA) and point mutation respectively. The advent and structural modeling of mupirocin has served as a paradigm for the clinical development and deployment of some other AaRs. This work reviewed the prospect of AaRS inhibitors as strong antibiotics.
Keywords: Aminoacyl-tRNA synthetase (AaRs), Staphylococcus aureus (S. aureus), aminoacyl-tRNAs (aa-rRNA) Drug, antibiotic,mechanism,inhibitor, drug resistance.
See first page preview PDF(53kb)
Purchase full article (N 1500)
 


Other scholarly works of Ononamadu CJ

Drug-Induced Mitochondria Toxicity

Related links

Disclaimer
Browse other scholarly works
Free online libraries
Publish your write ups, project works or books in the internet
Require assistance with the acquisition of free relevant literatures?
Require assistance with the statistical analysis of your data?
Require assistance with the graphical presentation of your results?
Require assistance with scientific research work?
Are you a Bioscientist? Browse lots of free online resources for a bioscientist

 

ufumes scholars affiliate program, click here for details

WARNINGS!

All transactions with UFUMES Scholars should be done with the contacts placed on this site.

We don’t approve and are not responsible for any financial transactions done with any of our affiliate member.

Please report such impersonating cases to us. You can contact us with +2348067817864 or mail us on scholars@ufumes.com.

Thanks for your trust and continued patronage.

QUICK LINKS

Publishing scholarly works online

Online Resources

Educational assistance

Nigerian Scholars forum

Other services/resources

 

Sponsored links

 

Hope we met your expectations . All we ask in return is that you tell some other Scholars about scholars.ufumes.com. You can also help us to serve you better. We are glad you visited. Thanks

Home | Contact Us | Advertisements | Disclaimer Policies | Site Map | Nigerian Bioscientist | About Us | Scholarly Works | Service | FAQs

scholars@ufumes.com
Copyright UFUMES® 2009
Mirror sites:http://scholars.ufumes.com , http://ufumesscholars.100webspace.net
Last updated on September 2009
Office: No 14 idiagba street Akure. Ondo State. Nigeria